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The amino acid change at 417 can be interesting. Within the South African B.1.351 variant, it is K417N. In the P.1 variant it is K417T. The amino acid change is completely different, however it seems to end in the same effect — enhancing evasion from antibodies. Preliminary studies reveal that position K417 is an important goal of neutralizing antibodies, too, suggesting that each mutations might help the virus evade vaccine-mediated and naturally acquired immunity.

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